This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may process memantine or amantadine more slowly.
What might happen:
The memantine or amantadine levels in your blood may increase and cause side effects such as dizziness, headache or confusion.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Contact you doctor if you have an increase in memantine side effects. The dose of your memantine or amantadine may need to be adjusted.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Namenda (memantine hydrochloride) US prescribing information. Forest Pharmaceuticals Inc. July, 2014.
2.Gocovri (amantadine) US Prescribing Information. Adamas Pharma, LLC August, 2017.
3.Goralski KB, Smyth DD, Sitar DS. In vivo analysis of amantadine renal clearance in the uninephrectomized rat: functional significance of in vitro bicarbonate-dependent amantadine renal tubule transport. J Pharmacol Exp Ther 1999 Aug;290(2):496-504.
4.Freudenthaler S, Meineke I, Schreeb KH, Boakye E, Gundert-Remy U, Gleiter CH. Influence of urine pH and urinary flow on the renal excretion of memantine. Br J Clin Pharmacol 1998 Dec;46(6):541-6.