Colchicine/HMG-CoA Reductase Inhibitors Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Colchicine may have adverse effects on muscles. HMG-CoA Reductase Inhibitors (statin) may have a similar.
What might happen:
The combination may increase the chance for muscle problems. You may experience muscle aches, tenderness, weakness, or tingling/numbness in the fingers or toes.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to order laboratory (blood) tests or decrease the dose of one or both medicines.Tell your doctor right away if you experience tingling/numbness in the fingers or toes, or have unexplained muscle pain, tenderness, or weakness.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Colcrys (colchicine) tablets, US prescribing information. Takeda Pharmaceuticals America Inc. December, 2015.
- 2.Crestor (rosuvastatin calcium) US prescribing information. AstraZeneca Pharmaceuticals LP May, 2016.
- 3.Lescol (fluvastatin sodium) US prescribing information. Novartis Pharmaceuticals Corporation October, 2012.
- 4.Tufan A, Dede DS, Cavus S, Altintas ND, Iskit AB, Topeli A. Rhabdomyolysis in a patient treated with colchicine and atorvastatin. Ann Pharmacother 2006 Jul-Aug;40(7-8):1466-9.
- 5.Atasoyu EM, Evrenkaya TR, Solmazgul E. Possible colchicine rhabdomyolysis in a fluvastatin-treated patient. Ann Pharmacother 2005 Jul-Aug; 39(7-8):1368-9.
- 6.Alayli G, Cengiz K, Canturk F, Durmus D, Akyol Y, Menekse EB. Acute myopathy in a patient with concomitant use of pravastatin and colchicine. Ann Pharmacother 2005 Jul-Aug;39(7-8):1358-61.
- 7.Justiniano M, Dold S, Espinoza LR. Rapid onset of muscle weakness (rhabdomyolysis) associated with the combined use of simvastatin and colchicine. J Clin Rheumatol 2007 Oct;13(5):266-8.
- 8.Hsu WC, Chen WH, Chang MT, Chiu HC. Colchicine-induced acute myopathy in a patient with concomitant use of simvastatin. Clin Neuropharmacol 2002 Sep-Oct;25(5):266-8.