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    Abitrexate (PF) Solution

    precautions

    What should I know regarding pregnancy, nursing and administering Abitrexate (PF) Solution to children or the elderly?

    If you are:

    Pregnant:

    Absolute Contraindication: REPORTS OF EMBRYOTOXICITY, FETAL DEATH, ABORTION

    Nursing:

    Absolute Contraindication: LOW LEVELS EXCRETED; POTENTIAL FOR SERIOUS ADVERSE EFFECTS IN INFANT

    An adult over 60:

    management or monitoring precaution: Renal- Consider lower dose. Monitor closely for early signs of renal, hepatic and bone toxicity especially with renal impairment Hepatic-Monitor LFTs regularly Hematologic-Monitor CBC regularly. Consider folate supplement with chronic use Pulmonary-Monitor closely for symptoms suggestive of fibrosis.

    Giving Abitrexate (PF) Solution to a child under 12:

    management or monitoring precaution: Increased neurotoxicity when used for acute lymphocytic leukemia.

    Severe Precaution: Caution with immature renal function. Seizure risk in acute lymphocytic leukemia.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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