If you are:
Absolute Contraindication: REPORTS OF EMBRYOTOXICITY, FETAL DEATH, ABORTION
Absolute Contraindication: LOW LEVELS EXCRETED; POTENTIAL FOR SERIOUS ADVERSE EFFECTS IN INFANT
An adult over 60:
management or monitoring precaution: Renal- Consider lower dose. Monitor closely for early signs of renal, hepatic and bone toxicity especially with renal impairment Hepatic-Monitor LFTs regularly Hematologic-Monitor CBC regularly. Consider folate supplement with chronic use Pulmonary-Monitor closely for symptoms suggestive of fibrosis.
Giving Abitrexate (PF) Solution to a child under 12:
management or monitoring precaution: Increased neurotoxicity when used for acute lymphocytic leukemia.
Severe Precaution: Caution with immature renal function. Seizure risk in acute lymphocytic leukemia.