Aripiprazole/Select Strong CYP2D6 Inhibitors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Some medicines may slow down how quickly your liver processes aripiprazole.

What might happen:

The amount of aripiprazole in your blood may increase and cause more side effects than normal.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change the dose of your aripiprazole while you are taking fluoxetine or paroxetine or quinidine. Let your doctor know if you notice an increase in side effects while taking these medicines together, especially any restlessness, muscle or joint stiffness, confusion, sweating, involuntary movements, dizziness or fainting when getting up from a seated or lying position, or have nausea or vomiting.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Abilify (aripiprazole) US prescribing information. Otsuka America Pharmaceutical, Inc. January, 2016.
  • 2.This information is based on or an extract from the UW Metabolism and Transport Drug Interaction Database (DIDB) Platform, Copyright University of Washington 1999-2014..
  • 3.Abilify Maintena (aripiprazole ext-rel inj.) prescribing information. Otsuka Pharmaceuticals January, 2016.
  • 4.Aristada (aripiprazole lauroxil) extended-release injectable US prescribing information. Alkermes Inc. October, 2015.