arthritis of the spine, resembling rheumatoid arthritis, which may progress to bony ankylosis with ossification of the anterior and posterior longitudinal ligaments; the disease is more common in males, often with the rheumatoid factor absent and the HLA antigen present. There is a striking association with the B27 tissue type and the strong familial aggregation suggests an important genetic factor, perhaps inherited as an autosomal dominant [MIM*106300]; the mechanism, however, remains obscure.
Syn: Marie-Strümpell disease, rheumatoid spondylitis, Strümpell-Marie disease
Back to Dictionary
WebMD Medical Reference from "Stedman's Medical Dictionary"
The publisher is not responsible (as a matter of product liability,
negligence or otherwise) for any injury resulting from any material contained
herein. This publication contains information relating to general principles of
medical care which should not be construed as specific instructions for
individual patients. Manufacturers’ product information and package inserts
should be reviewed for current information, including contraindications,
dosages and precautions.
Stedman’s Medical Dictionary 28th Edition, Copyright© 2006_Lippincott Williams & Wilkins. All rights reserved.