Well... after being diagnosed with Bipolar Disorder, the first med I tried was actually a mood stabilizer, Depakote. When that proved to not be enough, my psychiatric nurse practitioner added Latuda to the mix. For the first few months it worked great! Pulled me out of my depressive slumps, calmed my anxiety and kept me fairly stable. After a while though I began to experience this nasty side effect, and, unfortunately, not one that was listed, but something completely different and weird... a hyperactive gagging reflex. Basically, at seemingly random times (though it did seem worse when I was experiencing excess mucus in my throat) it would suddenly cause me to gag as if I was about to puke, but it wasn't my stomach that was upset, as I didn't feel nauseous, it was my throat muscles themselves. It made it somewhat difficult to eat, drink or even swallow my spit when I was feeling like that. Initially my doc thought it was developing tardive dyskinesia, so she added a med to help with that. Sadly, that medication didn't do anything to stop the gagging! Saw a ENT specialist about it to check my ears, nose, throat and sinuses, and they couldn't find anything wrong! Fast forward a few months and there were some on and off major life changes that were going on in my family and friends group, and my episodes of depression and anxiety returned, albeit slightly less intense, but still enough to disrupt my life. Upping the dosage of the Latuda helped with that, but I was still experiencing that frustrating and awful gagging reflex trigger! Finally, after moving to another state and due to insurance issues and such, I wasn't able to cover the cost of the Latuda, so I had to quit it cold turkey. WORST MISTAKE EVER! At first it was fine, nothing seemed to happen, but after a few weeks, my mood episodes started getting worse and worse. I started experiencing a weird "Self-aware Paranoia" in which I would be unable to trust most of my friends or family, and felt like they were all against me to ruin a facet of my life or other relationships in my life, DESPITE knowing in the back of my mind that that was ridiculous.... I couldn't stop the feelings and acted on them accordingly. This was in the midst of terrible mixed episodes with erratic sleep, bad hygiene, irritability and rage (which I'd never had issues with before), worsened anxiety, and other nasty symptoms.... The only good thing about cutting the med out of my life was the fact that THE GAG REFLEX IS GONE NOW! I can eat, drink and swallow just fine, nothing feels like it'll come back up, and physically I'm back to normal. My doc agreed that was prolly a weird, very rare side effect. Since then my family moved back to the state I was originally from, so I'm able to see the nurse practitioner who originally prescribed me Latuda and we both agreed to try another medication instead. So, overall, medication is a very selective, and individual experience. For some, I know Latuda works wonders, for others, they've had even worse outcomes than I did. All I can say is, give it a try, but do be warned that having side effects that AREN'T listed is a real possibility.Read More Read Less