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Risperdal

Interactions

Voriconazole/Selected QT Prolongers

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Voriconazole can affect your heart's rhythm. Other drugs can have the same effect.

What might happen:

Taking voriconazole with other agents that can affect your heart rhythm may increase your risk of an irregular heartbeat, which may be life-threatening.

What you should do about this interaction:

Let your healthcare professionals (e.g doctor or pharmacist) know that you are taking these medications together. Your doctor may want to perform an electrocardiogram (ECG) on you to check your heart's rhythm. Let your doctor know right away if you notice an irregular heartbeat or have any dizziness or fainting episodes.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47.

2.Saphris (asenapine) US prescribing information. Schering Corporation October, 2011.

3.Procoralan (ivabradine hydrochloride) summary of product characteristics. Servier December, 2005.

4.Serentil (mesoridazine besylate) US prescribing information. Novartis Pharmaceuticals Corporation August, 2000.

5.Avelox (moxifloxacin hydrochloride) US prescribing information. Bayer Pharmaceuticals Corporation August, 2013.

6.Invega (paliperidone) US prescribing information. Janssen Pharmaceuticals, Inc. April, 2011.

7.Rythmol (propafenone hydrochloride) US prescribing information. Abbott Laboratories March, 2013.

8.Seroquel (quetiapine fumarate) US prescribing information. AstraZeneca Pharmaceuticals LP July, 2011.

9.Qualaquin (quinine sulfate) US prescribing information. AR Scientific, Inc. April, 2013.

10.Xenazine (tetrabenazine) US prescribing information. Ovation Pharmaceuticals, Inc. September, 2008.

11.Caprelsa (vandetanib) US prescribing information. AstraZeneca Pharmaceuticals LP July, 2013.

12.Javlor (vinflunine ditartrate) UK Summary of Product Characteristics. Pierre Fabre Limited September 21, 2009.

13.Clopixol (zuclopenthixol acetate) UK summary of product characteristics. Lundbeck House October 24, 2008.

14.Apokyn (apomorphine hydrochloride) US prescribing information. Tercica, Inc. July, 2010.

15.Cipro (ciprofloxacin hydrochloride) US prescribing information. Bayer Corporation August, 2013.

16.Clozaril (clozapine tablets) US prescribing information. Novartis Pharmaceuticals Corporation March, 2013.

17.Anzemet (dolasetron mesylate) US prescribing information. Sanofi-Aventis Us.S. LLC September, 2013.

18.Mathivanan M. Dear Canadian Healthcare Professional: Subject: Association of domperidone maleate with serious ventricular arrhythmias and sudden cardiac death. Teva Canada Limited March 2, 2012.

19.Foradil Aerolizer (formoterol fumarate) US prescribing information. Schering Corporation September, 2012.

20.Tequin (gatifloxacin) US prescribing information. Bristol-Myers Squibb Company January, 2006.

21.Factive (gemifloxacin mesylate) US prescribing information. Oscient Pharmaceuticals August, 2013.

22.Haldol (haloperidol) US prescribing information. Ortho-McNeil-Janssen Pharmaceuticals, Inc. August, 2011.

23.Levaquin (levofloxacin) US prescribing information. Ortho-McNeil Pharmaceutical, Inc. August, 2013.

24.NegGram (nalidixic acid) US prescribing information. Sanofi-Synthelabo, Inc. November, 2012.

25.Noxafil (posaconazole) UK summary of product characteristics. Schering-Plough Ltd. February 2, 2006.

26.Edurant (rilpivirine) US prescribing information. Tibotec Pharmaceuticals June, 2013.

27.Risperidal (risperidone) UK summary of product characteristics. Janssen-Cilag, UK Limited May 14, 2004.

28.Tikosyn (dofetilide) US prescribing information. Pfizer Inc. December, 2013.

29.Betapace (sotalol hydrochloride) US prescribing information. Berlex Laboratories August, 2011.

30.Vibativ (telavancin) US prescribing information. Astellas Pharma US, Inc. September, 2009.

31.The University of Arizona Center for Education and Research of Therapeutics. Drugs with Risk of Torsades de Pointes and Drugs with Possible Risk of Torsades de Pointes. Available at:http://www.crediblemeds.org/. Updated March 14, 2013.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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