If you are:
Only When Necessary: REPORTS OF ARTHROPATHY WITH QUINOLONES IN ANIMAL STUDIES; CONSIDER RISK/BENEFIT
Precaution: INSUFFICIENT DATA AVAILABLE; LIMITED DATA SUGGEST MINIMAL AMOUNT EXCRETED
An adult over 60:
management or monitoring precaution: Musculoskeletal-Risk for tendinitis and tendon rupture increases with concomitant corticosteroid use. Cardiovascular-Elderly may be more susceptible to QT-prolongation. Monitor and correct electrolytes (e.g., K, Mg). Neuro/Psych-Risk for peripheral neuropathy which may affect walking and increase fall risk. Renal-Adjust dose for CrCL< 50 mL/min.
Giving Ciprofloxacin to a child under 12:
Severe Precaution: Potential risk of musculoskeletal adverse reactions. Arthropathy and cartilage erosion observed in juvenile animal studies. No safety and efficacy age < 1 year. Rare use for plague, anthrax, or other circumstances of multidrug resistant bacteria.
Severe Precaution: Increased risk of musculoskeletal adverse reaction, tendinitis, tendon rupture during or post treatment. Immediate release oral dose form approved for age>1 year.