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sildenafil

Interactions

Sildenafil; Tadalafil/Potent CYP 3A4 Inhibitors

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Some medicines may slow down how quickly your liver processes sildenafil and tadalafil.

What might happen:

Your blood levels of sildenafil and tadalafil may increase and cause harmful effects.

What you should do about this interaction:

Let your healthcare professional (e.g. doctor or pharmacist) know that you are taking these medicines together and if you are taking sildenafil or tadalafil for erectile dysfunction or a lung disease called pulmonary hypertension. Your doctor may want to change the dose of your sildenafil or tadalafil or change your other medicine.Contact your healthcare professional right away if you experience a painful or prolonged erection, fainting or dizziness, or changes in vision.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Viagra (sildenafil) US prescribing information. Pfizer Inc. March, 2014.

2.Cialis (tadalafil) US prescribing information. Eli Lilly and Company February, 2010.

3.Revatio (sildenafil citrate) US prescribing information. Pfizer Inc. March, 2014.

4.Adcirca (tadalafil) US prescribing information. Eli Lilly and Company February, 2011.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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