Skip to content
My WebMD Sign In, Sign Up

simvastatin

Interactions

Lovastatin; Simvastatin/Conivaptan

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Conivaptan may slow down how quickly your liver processes lovastatin and simvastatin.

What might happen:

The amount of lovastatin or simvastatin in your body may increase and cause more side effects than normal.

What you should do about this interaction:

Let your healthcare professional (e.g. doctor or pharmacist) know right away that you are taking these two medications together. Your doctor may instruct you not to take your cholesterol medicine while you are receiving conivaptan or your doctor may change your cholesterol medicine.Contact your healthcare professional if you experience muscle weakness, aches, tenderness, or pain, flu-like symptoms, or discoloration of your urine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Mevacor (lovastatin) US prescribing information. Merck & Co., Inc. February, 2014.

2.Vaprisol (conivaptan hydrochloride) US prescribing information. Astellas Pharma US, Inc. February, 2012.

3.Zocor (simvastatin) US prescribing information. Merck & Co., Inc. February, 2014.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

More about Drugs and Medications

Newsletters

Subscribe to free WebMD newsletters.

  • WebMD Daily

    WebMD Daily

    Subscribe to the WebMD Daily, and you'll get today's top health news and trending topics, and the latest and best information from WebMD.

  • Men's Health

    Men's Health

    Subscribe to the Men's Health newsletter for the latest on disease prevention, fitness, sex, nutrition, and more from WebMD.

  • Women's Health

    Women's Health

    Subscribe to the Women's Health newsletter for the latest on disease prevention, fitness, sex, diet, anti-aging, and more from WebMD.

By clicking Submit, I agree to the WebMD Terms & Conditions & Privacy Policy

URAC: Accredited Health Web Site TRUSTe online privacy certification HONcode Seal AdChoices