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Drugs & Medications

naloxone injection

COMMON BRAND NAME(S): Evzio

GENERIC NAME(S): NALOXONE HCL

Uses

This medication is used for the emergency treatment of known or suspected narcotic (opiate) overdose. Serious overdose symptoms may include unusual sleepiness, unusual difficulty waking up, or breathing problems (ranging from slow/shallow breathing to no breathing). Other symptoms of overdose may include very small "pinpoint" pupils, slow heartbeat, or low blood pressure. If someone has serious overdose symptoms but you are not sure if he or she has overdosed, give this medication right away anyway, since lasting slow/shallow breathing may cause permanent damage to the brain or death.

This medication belongs to a class of drugs known as narcotic (opiate) antagonists. It works by blocking the effects of the narcotic in the brain. This medication may not work as well to block the effects of certain types of narcotics (mixed agonist/antagonists such as buprenorphine, pentazocine). With these types of narcotics, blocking may be incomplete or you may need a higher dose of naloxone.

The effects of naloxone will not last as long as the effects of the narcotic. Since treatment with this medication is not long-lasting, be sure to get medical help right away after giving the first dose of naloxone. Treatment of narcotic overdose should also include breathing treatment (such as oxygen given through tubes in the nose, mechanical ventilation, artificial respiration).

How to use naloxone injection

See also Uses section.

Read the Patient Information Leaflet and Instructions for Use provided by your pharmacist when you get this medication and each time you get a refill. Be sure to keep this medication handy in case it is needed. Learn ahead of time how to properly inject this medication and practice with the trainer device so you will be ready to use naloxone if needed. If you have any questions, ask your doctor or pharmacist.

The solution in this product should be clear. Check this product visually for particles or discoloration from time to time. If the solution is cloudy, discolored, or contains solid particles, replace it with a new auto-injector. (See also Storage section.)

Avoid accidentally injecting this medication into your hands or areas of the body other than the thigh. If this happens, tell the healthcare professional immediately.

The effects of this medication are rapid but not long-lasting. After giving naloxone, get medical help right away, even if the person wakes up. If symptoms return after giving an injection, give another naloxone injection using a new auto-injector every 2 to 3 minutes if available. Each auto-injector contains only one dose and cannot be reused. Continue to closely watch the person until emergency help is received. Tell the healthcare professional that you have given an injection of naloxone.

Side Effects

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

In someone who has been using a narcotic regularly, withdrawal symptoms can happen suddenly after receiving this medication. Withdrawal symptoms may include body aches, fever, sweating, watering eyes, runny nose, sneezing, goose bumps, yawning, weakness, shivering/trembling, nervousness, restlessness, diarrhea, nausea/vomiting, stomach cramps, increased blood pressure, fast heartbeat. In babies younger than 4 weeks who have been receiving a narcotic regularly, sudden narcotic withdrawal may be life-threatening if not treated the right way. Symptoms in babies may include seizures, crying more than usual, and muscle twitching/spasms.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using this medication, tell your doctor or pharmacist if you are allergic to naloxone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as irregular heartbeat, previous heart attack).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. It may cause narcotic withdrawal in an unborn baby whose mother has been regularly taking a narcotic. The doctor will carefully monitor both the pregnant woman and the unborn baby after this medication is given. Ask your doctor for details.

It is unknown if this medication passes into breast milk. However, it is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Overdose

Overdose in somebody not regularly taking a narcotic is highly unlikely. However, if overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

The severity of withdrawal symptoms and how long they last depend on the dose of naloxone as well as the degree and type of narcotic dependence.

Missed Dose

Not applicable.

Storage

Store this product and the trainer device in the carrying case/original packaging at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

From time to time, check the expiration date, and check this product visually for particles or discoloration. Replace the device before it expires or if it has particles/discoloration.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this medication when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised June 2014. Copyright(c) 2014 First Databank, Inc.

Images

NALOXONE 0.4 MG/ML AMPUL
NALOXONE 0.4 MG/ML AMPUL
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NALOXONE 0.4 MG/ML VIAL
NALOXONE 0.4 MG/ML VIAL
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NALOXONE 0.4 MG/ML AMPUL
NALOXONE 0.4 MG/ML AMPUL

Identification

color
clear
shape
No data.
imprint
No data.
This medicine is a clear, clear solution.
NALOXONE 0.4 MG/ML VIAL
NALOXONE 0.4 MG/ML VIAL

Identification

color
colorless
shape
No data.
imprint
No data.
This medicine is a colorless, clear vial.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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