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Quinolones, Oral/Sucralfate

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not absorb your antibiotic properly.

What might happen:

The blood levels of your antibiotic may decrease and reduce the effectiveness of the medicine in treating your infection.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these medicines together. You may need to modify your medicine schedule to take your antibiotic at least 2 hours before sucralfate. They may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.


1.Hoffken G, Lode H, Wiley R, Glatzel TD, Sievers D, Olschewski T, Borner K, Koeppe T. Pharmacokinetics and bioavailability of ciprofloxacin and ofloxacin: effect of food and antacid intake. Rev Infect Dis 1988;10(Supp 1):S138-9.

2.Parpia SH, Nix DE, Hejmanowski LG, Goldstein HR, Wilton JH, Schentag JJ. Sucralfate reduces the gastrointestinal absorption of norfloxacin. Antimicrob Agents Chemother 1989 Jan;33(1):99-102.

3.Grasela TH Jr, Schentag JJ, Sedman AJ, Wilton JH, Thomas DJ, Schultz RW, Lebsack ME, Kinkel AW. Inhibition of enoxacin absorption by antacids or ranitidine. Antimicrob Agents Chemother 1989 May;33(5):615-7.

4.Nix DE, Watson WA, Handy L, Frost RW, Rescott DL, Goldstein HR. The effect of sucralfate pretreatment on the pharmacokinetics of ciprofloxacin. Pharmacotherapy 1989;9(6):377-80.

5.Yuk JH, Nightingale CN, Quintiliani R. Ciprofloxacin levels when receiving sucralfate. JAMA 1989 Aug 18;262(7):901.

6.Brouwers JRBJ, Van der Kam HJ, Sijtsma J, Proost JH. Important reduction of ciprofloxacin absorption by sucralfate and magnesium citrate solution. Drug Invest 1990;2(3):197-9.

7.Garrelts JC, Godley PJ, Peterie JD, Gerlach EH, Yakshe CC. Sucralfate significantly reduces ciprofloxacin concentrations in serum. Antimicrob Agents Chemother 1990 May;34(5):931-3.

8.Van Slooten AD, Nix DE, Wilton JH, Love JH, Spivey JM, Goldstein HR. Combined use of ciprofloxacin and sucralfate. DICP 1991 Jun;25(6):578-82.

9.Yuk JH, Williams TW Jr. Drug interaction with quinolone antibiotics in intensive care unit patients. Arch Intern Med 1991 Mar;151(3):619.

10.Lomaestro BM, Bailie GR. Quinolone-cation interactions: a review. DICP 1991 Nov;25(11):1249-58.

11.Kawakami J, Matsuse T, Kotaki H, Seino T, Fukuchi Y, Orimo H, Sawada Y, Iga T. The effect of food on the interaction of ofloxacin with sucralfate in healthy volunteers. Eur J Clin Pharmacol 1994;47(1):67-9.

12.Lehto P, Kivisto KT. Different effects of products containing metal ions on the absorption of lomefloxacin. Clin Pharmacol Ther 1994 Nov; 56(5):477-82.

13.Lehto P, Kivisto KT. Effect of sucralfate on absorption of norfloxacin and ofloxacin. Antimicrob Agents Chemother 1994 Feb;38(2):248-51.

14.Factive (gemifloxacin mesylate) US prescribing information. Oscient Pharmaceuticals August, 2013.

15.Allen A, Bygate E, Faessel H, Isaac L, Lewis A. The effect of ferrous sulphate and sucralfate on the bioavailability of oral gemifloxacin in healthy volunteers. Int J Antimicrob Agents 2000 Aug;15(4):283-9.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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